Cushing's and Lysodren

Maggie Moo is 14 1/2 and she has been treated with Lysodren for Cushing's for well over 4 years and has done well. in the last months she has become very weak in her hind quarters. We have to lift her up 90% of the time and she falls over if there is a strong breeze. Painful to see. She has recently begun to limp on her front right leg. At first we though she has strained something in an attempt to get up but it seems to be more than that. I'm beginning to wonder if the Lysodren is causing her arthritis to flare up due to the suppressed cortisol levels.

The vet wants her to come in for all sorts of tests but I'm not willing to put her thru that at this point. She has a breakdown everytime she has to go there and it takes forever for her to recover what little strength she has after the visits.

I'm considering not giving her the lysodren for a few weeks and seeing if there is an improvement in the leg pain she seems to be experiencing. It is all about the quality of life at this point. She still enjoys and good meal (since her weight is no longer an issue McDonald's double cheese burger are a favorite) and enjoyed a short walk until recently. I'd like her to be able to enjoy the remainder of her days with as little pain as can be.

Any guidance or experience would be appreciated.

Lorraine
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It's so hard to watch our kids grow older and making it to 14-1/2 is doing quite well if Maggie Moo is an OES. Our Winston had Cushings and was treated with Lysodren, diagnosed when he was about 7 yrs. of age. He lived to just short of 14. By then he was also arthritic in his hind quarters and having some trouble getting up. Pneumonia is what ultimately took him from us. We never suspected the Lysodren to be the cause as he had already lived a good, long life.

I don't blame you for not wanting additional tests. The stress wouldn't be worth it and honestly, she may not gain anything in time or quality of life. Did your vet give you any idea of how quickly the Cushings symptoms would return after stopping the Lysodren? Please discuss this with your vet and follow your heart on your decision.
Thank you for the reply. Was Winston on a maintanance dose of Lysodren from the time of his diagnosis to the age of 14? Maggie is an OES and has been a good friend for over 14 years. My husband and I are not on the same page. If she gets up by herself or walks around a bit he feels that she is 'getting better'. I just see her as being in pain. I think we will make an appointment to speak with her vet and see what he thinks regarding the Lysodren. I certainly do not want to make the matter worse for her.

Thanks you
It is always hard to decide what is best. This past fall Taylor started having trouble getting up and going out to go potty. We checked with the vet and she had gone into mild renal failure. We switched her diet and she perked up and would actually want to play some. We also added Rimadyl for her arthritis. We were able to have another 2 months with her and then she stopped eating and drinking. It was very hard but I was glad I had the few extra months and her pain seemed controlled. When she wouldn't want to get up or lay down from the pain I knew the time had come.

Talk with your vet. They may have a few more options for you. It still makes me sad to think about that time but I always remember we had 15 good years together and I did what I could to make those last few weeks good for her. You will know what is right for you and your baby.
When Winston was diagnosed (many years ago) Lysodren was the only drug out there for treatment. It was also very difficult to obtain and quite expensive because we could not find it in veterinary-grade. As I recall, he stayed on basically the same dosage from the time he was diagnosed until he left us.

A friend has a senior dog with Cushings where the vet opted to treat with Trilostane rather than Lysodren. PM me if you'd like and I will put you in touch with her.
Lysodren is still only made for human to the best of my knowledge. I know I have Maggies prescriptions filled at the local Costco and it usually is about $230 for 40 pills (about 2 months of dosage). The Vet has said that she has always been very well controlled on the Lysodren so there was no reason to change. In my heart I feel that she is just suffering with arthritis. She is also taking Rimadyl daily and that seemed to help for a bit but doesn't seem to be making much of an impact now.
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