2 year old rescue dog going in the house

I have a 2 year old i got from a shelter in october he has done great since day one but now suddenly he goes in his room when im not home or when im home and he is in his room alone.He usually sleeps in my room and never has a problem all night or during the day when im with him.He only pees in his room for anything else he uses his doggy door and goes outside.Ive tried cleaning his hole room with natures miracle and get serious odor extractor.Nothing seems to work anyone have any suggestions.
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I feel for you! I have a 1 year old great Dane and we are having the same issue she is well potty trained and for the last 4 days has been doing #1 and 2 in my home I am upset with her I am not sure why she is doing this I have started back at square one in the mean time I have been searching on line everyone says could be a health issue you might want to see a vet just to make sure is not an illness I have an appointment in a few days because my dog has been to training schools and trained and this is out of the blue. Goog luck sorry I couldn't be more help.
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